Andrew M Scott Selected Research

Hu3S193 monoclonal antibody

8/2015	A phase II trial with anti-Lewis-Y monoclonal antibody (hu3S193) for the treatment of platinum resistant/refractory ovarian, fallopian tube and primary peritoneal carcinoma.
1/2009	Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy.
10/2007	Targeting Lewis Y (Le(y)) in small cell lung cancer with a humanized monoclonal antibody, hu3S193: a pilot trial testing two dose levels.
6/2007	A phase I biodistribution and pharmacokinetic trial of humanized monoclonal antibody Hu3s193 in patients with advanced epithelial cancers that express the Lewis-Y antigen.
4/2006	Enhanced efficacy of 90Y-radiolabeled anti-Lewis Y humanized monoclonal antibody hu3S193 and paclitaxel combined-modality radioimmunotherapy in a breast cancer model.
8/2003	Generation of anti-idiotype antibodies for application in clinical immunotherapy laboratory analyses.

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Andrew M Scott Research Topics

Disease

135	Neoplasms (Cancer) 03/2022 - 02/2002
19	Glioblastoma (Glioblastoma Multiforme) 03/2021 - 05/2009
18	Neoplasm Metastasis (Metastasis) 01/2022 - 06/2004
18	Hypoxia (Hypoxemia) 01/2020 - 02/2002
17	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 07/2005
14	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 07/2005
13	Glioma (Gliomas) 09/2011 - 02/2002
10	Renal Cell Carcinoma (Grawitz Tumor) 07/2018 - 05/2002
10	Carcinoma (Carcinomatosis) 01/2018 - 08/2003
8	Melanoma (Melanoma, Malignant) 01/2021 - 10/2002
6	Breast Neoplasms (Breast Cancer) 01/2021 - 08/2003
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 06/2004
4	Brain Neoplasms (Brain Tumor) 01/2021 - 02/2002
4	Disease Progression 01/2021 - 06/2010
4	Malignant Mesothelioma 12/2020 - 06/2011
4	Squamous Cell Carcinoma (Epidermoid Carcinoma) 05/2015 - 02/2007
4	Lung Neoplasms (Lung Cancer) 06/2009 - 06/2004
3	Mesothelioma 10/2020 - 06/2011
3	Ischemic Stroke 01/2018 - 08/2012
2	Hematologic Neoplasms (Hematological Malignancy) 03/2022 - 10/2017
2	Non-Hodgkin Lymphoma (Lymphosarcoma) 03/2022 - 03/2009
2	Lymphoma (Lymphomas) 02/2022 - 03/2012
2	Hypertension (High Blood Pressure) 01/2022 - 02/2009
2	Oncogene Addiction 01/2020 - 05/2009

Drug/Important Bio-Agent (IBA)

38	Monoclonal AntibodiesIBA 10/2020 - 03/2002
32	ErbB Receptors (EGF Receptor)IBA 01/2021 - 01/2003
31	AntibodiesIBA 03/2022 - 03/2002
30	AntigensIBA 01/2021 - 05/2002
22	Proteins (Proteins, Gene)FDA Link 01/2021 - 05/2002
18	epidermal growth factor receptor VIIIIBA 03/2021 - 03/2002
15	Immunoconjugates (Immunoconjugate)IBA 03/2022 - 11/2009
13	monoclonal antibody 806IBA 05/2015 - 03/2002
12	LigandsIBA 01/2021 - 08/2004
12	fluoromisonidazoleIBA 01/2020 - 02/2002
10	EpitopesIBA 10/2020 - 07/2004
9	Biological ProductsIBA 10/2015 - 08/2005
7	Radioisotopes (Radionuclides)IBA 03/2022 - 02/2007
7	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2022 - 03/2006
7	depatuxizumab mafodotinIBA 01/2021 - 12/2017
7	Tyrosine Kinase InhibitorsIBA 01/2018 - 10/2005
7	Glucose (Dextrose)FDA LinkGeneric 07/2012 - 06/2004
6	Pharmaceutical PreparationsIBA 01/2021 - 10/2015
6	Eph Family Receptors (Eph Receptors)IBA 01/2021 - 02/2012
6	CarbohydratesIBA 10/2015 - 07/2004
6	Hu3S193 monoclonal antibodyIBA 08/2015 - 08/2003
5	EphrinsIBA 01/2022 - 08/2005
5	EnzymesIBA 01/2021 - 12/2006
5	Temozolomide (Temodar)FDA LinkGeneric 01/2021 - 12/2003
5	CytokinesIBA 09/2019 - 05/2002
5	VaccinesIBA 01/2017 - 07/2004
5	Phosphotransferases (Kinase)IBA 12/2014 - 02/2007
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2018
4	Androgen Receptors (Androgen Receptor)IBA 01/2021 - 01/2016
4	depatuxizumabIBA 01/2021 - 05/2015
4	Cetuximab (Erbitux)FDA Link 11/2015 - 02/2007
4	Therapeutic UsesIBA 11/2015 - 02/2007
4	Blood Group Antigens (Blood Groups)IBA 10/2015 - 07/2004
4	Lewis Y antigenIBA 08/2015 - 06/2007
4	PolymersIBA 08/2012 - 09/2007
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 11/2015
3	LipidsIBA 01/2021 - 11/2019
3	AndrogensIBA 01/2021 - 06/2009
3	ABT-414IBA 10/2020 - 07/2017
3	Cytotoxins (Cytolysins)IBA 01/2019 - 12/2005
3	Platelet-Derived Growth FactorIBA 01/2018 - 01/2018
3	platelet-derived growth factor C (PDGF-C)IBA 01/2018 - 01/2018
3	Epidermal Growth Factor (EGF)IBA 01/2016 - 06/2009
3	SulfoxidesIBA 01/2016 - 08/2012
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2016 - 12/2003
3	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 01/2016 - 11/2013
3	DisulfidesIBA 01/2016 - 09/2011
3	Serine Proteases (Serine Protease)IBA 11/2015 - 11/2012
3	Immunoglobulin G (IgG)IBA 08/2015 - 08/2008
3	Paclitaxel (Taxol)FDA LinkGeneric 01/2015 - 04/2006
3	Tyrosine (L-Tyrosine)FDA Link 12/2014 - 06/2009
3	Carbonic Anhydrase IXIBA 07/2011 - 07/2009
3	Interleukin-2 (IL2)IBA 08/2007 - 05/2002
2	Capecitabine (Xeloda)FDA Link 01/2022 - 04/2014
2	Bevacizumab (Avastin)FDA Link 01/2022 - 11/2015
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 03/2021 - 12/2020
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2021 - 01/2020
2	Fluorine-18IBA 01/2021 - 06/2004
2	Messenger RNA (mRNA)IBA 01/2021 - 12/2006
2	Phospholipids (Phosphatides)FDA LinkGeneric 01/2021 - 01/2021
2	fluoromethylcholineIBA 01/2021 - 01/2019
2	RadiopharmaceuticalsIBA 01/2021 - 01/2021
2	Lutetium-177IBA 01/2021 - 01/2009
2	Everolimus FDA Link 01/2020 - 01/2017
2	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2019 - 12/2015
2	monomethyl auristatin EIBA 01/2019 - 01/2018
2	IntegrinsIBA 01/2019 - 06/2015
2	gallium 68 PSMA-11IBA 01/2019 - 01/2018

Therapy/Procedure

70	Therapeutics 03/2022 - 03/2002
18	Drug Therapy (Chemotherapy) 01/2022 - 09/2005
14	Radiotherapy 02/2022 - 09/2005
10	Immunotherapy 01/2021 - 05/2002
10	Radioimmunotherapy 12/2016 - 07/2005
4	Precision Medicine 03/2022 - 01/2019
3	Castration 01/2021 - 10/2018
3	Prostatectomy (Retropubic Prostatectomy) 01/2019 - 05/2011